Quiz about preservation solution

Role of preservation solutions in transplantation

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The quality of organ preservation is a major determinant of initial graft function and survival. The purposes of flushing & preservation solution is varied and numerous, which of the above is false?

Complete hypothermic flushing (avoid aggregation)

Increase enzymatic activity.

Prevention of hypothermia-induced cellular swelling and oedema (membrane-impermeable substances & Oncotic agent)

Prevention of oxidative damage caused by free radicals (Reduced glutathione - Mannitol - Allopurinol)

Prevention of tissue acidosis caused by lactic acid accumulation (Histidine, Phosphate)

Prevention of energy loss (adenosine, glutamate)

Ischemia-reperfusion Injury (IRI) & preservation solution

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Ischemia-reperfusion injury (IRI) is unavoidable consequence in transplantation and have influences on short term as well as long-term graft outcome. Which of the following complications is caused by Ischemia-reperfusion?

Oxidative damage caused by free radicals

Cellular swelling and oedema

Calcium loading

Lost of high-energy substances

Tissue acidosis, caused by lactic acid accumulation

All of them

Role of Oncotic Agents

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The UW solution contains oncotic agent Hydroxyethyl starch (HES), which has been replaced by polyethylene glicol 35kDa (PEG35) in IGL-1 solution. Why?

To reduce viscosity and To decrease red blood cell aggregation

To avoid the water extravasation to the interstitial space and limits therefore the interstitial edema

Extracellular definition

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An extracellular preservation solution, compare to an intracellular solution, is determine by a ionic balance close to the extracellular ratios of Na⁺/K^+..But what is this ratios?

Na+ ≥ 100mmol /L and K+. ≤ 30mmol / L.

Na+ ≥ 30mmol / L. and K+. ≤ 100mmol /L

DONATION AFTER CIRCULATORY ARREST (MAASTRICHT III)

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In 🇫🇷, what type of preservation solution is recommended by the French Agency of Biomedicine to perform the perfusion and washout the organ, by donation after circulatory arrest (Maastricht category 3) ?

intracellular preservation solution

extracellular preservation solution

extracellular preservation solution containing colloids.

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